The Longevity Genes — What Epigenetics Can Teach Us About Aging Better
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Your genes are not your destiny. Epigenetics studies how lifestyle “marks” on DNA influence which genes turn on or off—without changing the sequence. That means daily choices can tilt expression toward repair, resilience, and longevity.
“You can’t swap the blueprint—but you can guide how it’s read.”
Key Longevity Pathways Influenced by Lifestyle
- SIRT1/SIRT3: Cellular stress resistance & mitochondrial function
- AMPK & mTOR: Nutrient sensing, autophagy, repair
- FOXO3: Oxidative stress defense and lifespan associations
- Nrf2: Detoxification and antioxidant gene activation
- DNA methylation: Epigenetic “clock” linked to biological age
Daily Practices That Nudge Genes in the Right Direction
- Time-restricted eating: 12–14 hour nightly fast to stimulate AMPK and autophagy.
- Strength + intervals: Exercise activates PGC-1α and mitochondrial biogenesis.
- Circadian alignment: Morning light, consistent sleep/wake, minimize late-night eating.
- Reduce toxic load: Stainless/ceramic cookware, filtered water, fewer ultra-processed foods.
Young Again Nutrients That Support Epigenetic Health
- Young Again Curcumin: Influences histone/epigenetic modulation and Nrf2 activation.
- Young Again Alpha Lipoic Acid: Supports mitochondrial renewal and redox balance.
References
- Sinclair, D. A., & LaPlante, M. D. (2019). Lifespan: Why We Age—and Why We Don't Have To. Atria.
- Fraga, M. F., & Esteller, M. (2007). Epigenetics and aging. Dev Dyn, 236(10), 2627–2634.
- Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome Biology, 14(10), R115.